Unpacking extracellular vesicles: RNA cargo loading and function

Extracellular vesicles (EVs) are a heterogeneous group of membrane-enclosed structures produced by prokaryotic and eukaryotic cells. EVs carry range biological cargoes, including RNA, protein, lipids, which may have both metabolic significance signalling potential. EV release has been suggested to play critical role in maintaining intracellular homeostasis eliminating unnecessary material from producing cells, as delivery system enable cellular communication between neighbouring distant cells without physical contact. In this review, we give an overview what is known about the relative enrichment different types RNA that associated with most recent research efforts. We then examine selective non-selective incorporation these biotypes into EVs, molecular systems sorting elucidated so far, process EV-producing Finally, also discuss model providing evidence for EV-mediated recipient implications relevance physiological pathological scenarios.